Our paper has been published in Science Immunology
Our paper entitled “Celastrol suppresses humoral immune responses and autoimmunity by targeting the COMMD3/8 complex” has been published in Science Immunology.
We previously reported that a protein complex consisting of COMMD3 and COMMD8 (COMMD3/8 complex) acts as a positive regulator of chemoattractant receptor signaling and plays important roles in the control of B cell migration and humoral immune responses. In this study, we show that the COMMD3/8 complex promotes disease progression in a mouse model of rheumatoid arthritis. Additionally, the COMMD3/8 complex is found to serve as a pharmacological target of celastrol, an anti-inflammatory drug with a poorly defined mechanism of action. This study suggests that the COMMD3/8 complex is a potential therapeutic target in autoimmune diseases.
